Another, well-done, failure of replication study discussed in Nature--this one focused on basic methods

[IbogaProject]

2. mouse models especially

Did they do a reddo of the "give rats unlimited access to drugs" and if the environment wasn't bare and had stuff to do and other mice to interact with they don't even use drugs, let alone abuse. And those diets are another area that really alters outcomes, as many of those special diets are missing key nutrients, which help simulate worst case effects but can lead to things like the saccharine scare. And the publish or perish system actually rewards fraud as it is easier to hit the mark often, where legitimate honest research will fail quite a bit.